Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects

By |2018-02-05T16:45:33-05:00February 5th, 2018|Categories: DSF Research Review|Tags: , |

(Eimon et al. 2018) In this study, the authors used two Dravet-like zebrafish models, each with a different mutation, to describe a method of monitoring zebrafish larvae via implanted electrodes (as opposed to external EEG-like electrodes) to predict drug efficacy and side effects. This method uses several measurements of brain activity patterns both during and [...]

Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome.

By |2017-08-23T22:42:28-05:00August 23rd, 2017|Categories: DSF Research Review|Tags: , , |

(Grone B, et al. 2017). Anti-epileptic drug (AED) screening in zebrafish has proven efficient in models of Dravet syndrome due to the lower cost of maintaining fish compared with mouse colonies and rapid reproduction rates. The zebrafish used to study Dravet syndrome carry mutations in scn1lab (a zebrafish version of the human SCN1A gene) and are [...]

Pharmacological analysis of the anti-epileptic mechanisms of fenfluramine in SCN1A mutant zebrafish

By |2017-06-24T03:51:07-05:00May 8th, 2017|Categories: DSF Research Review|Tags: , , , |

(Sourbron J et al. 2017). Fenfluramine (FA) is known to affect serotonin (5-HT) levels in the brain, but there are several different 5-HT receptor subtypes that may be involved in FA's mechanism of action. This study explored the anti-epileptic mechanisms of FA in SCN1Lab-mutant zebrafish by selectively targeting each of the receptors believed to be involved [...]