Impaired intracortical inhibition demonstrated in vivo in people with Dravet syndrome

By |2017-03-31T20:50:48-05:00March 31st, 2017|Categories: DSF Research Review|Tags: , |

Most mouse models of Dravet syndrome have supported the theory that SCN1A mutations affect inhibitory neurons more than excitatory neurons, resulting in a the inhibitory neurons' failure to activate and counteract excitation. Various theories exist for why excitatory neurons are able to compensate for the loss of SCN1A function due to mutations, including the ability [...]