Time of Day and a ketogenic diet Influence Susceptibility to SUDEP in Scn1aR1407X/+ Mice

By |2019-05-09T14:50:11-05:00May 9th, 2019|Categories: DSF Research Review|Tags: , , , , , , , |

This article brought forth some interesting observations.  First, a major caveat - this study was done in mice.  Mice with a relevant mutation in the Scn1a gene have proven to be a useful model of Dravet, but one must never directly extrapolate any results to humans.  Dividing the day into three 8-hour periods, it [...]

Sleep problems in Dravet syndrome: a modifiable comorbidity

By |2018-01-22T16:47:16-05:00January 22nd, 2018|Categories: DSF Research Review|Tags: |

(Licheni et al. 2017) 57 patients from Australia completed a sleep questionnaire, with 75% reporting problems. The most commonly reported problem was difficulty initiating and maintaining sleep, with sleep-wake transition disorders second most common. 53%  had nocturnal seizures. 16 patients were monitored by pulse oximetry overnight, and 14 of those had a higher than normal [...]

Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome.

By |2017-08-23T22:42:28-05:00August 23rd, 2017|Categories: DSF Research Review|Tags: , , |

(Grone B, et al. 2017). Anti-epileptic drug (AED) screening in zebrafish has proven efficient in models of Dravet syndrome due to the lower cost of maintaining fish compared with mouse colonies and rapid reproduction rates. The zebrafish used to study Dravet syndrome carry mutations in scn1lab (a zebrafish version of the human SCN1A gene) and are [...]

Age-related “Sleep/nocturnal” tonic and tonic clonic seizure clusters are underdiagnosed in patients with Dravet syndrome

By |2017-07-22T16:02:18-05:00July 22nd, 2017|Categories: DSF Research Review|Tags: , |

(Losito E, et al. 2017) Of 33 patients with Dravet syndrome older than eleven years in a French cohort, 26 experienced a switch from mainly daytime seizures to mainly sleep/nocturnal (S/N) seizures between age 4 and age 11. The S/N seizures were usually brief, often occurred in clusters of 2-15 per night, and were often [...]

Go to Top