Time of Day and a ketogenic diet Influence Susceptibility to SUDEP in Scn1aR1407X/+ Mice

By |2019-05-09T14:50:11-05:00May 9th, 2019|Categories: DSF Research Review|Tags: , , , , , , , |

This article brought forth some interesting observations.  First, a major caveat - this study was done in mice.  Mice with a relevant mutation in the Scn1a gene have proven to be a useful model of Dravet, but one must never directly extrapolate any results to humans.  Dividing the day into three 8-hour periods, it [...]

Long-term safety and efficacy of cannabidiol in children and adults with treatment resistant Lennox-Gastaut syndrome or Dravet syndrome: Expanded access program results

By |2019-05-09T14:49:00-05:00May 9th, 2019|Categories: DSF Research Review|Tags: , , , , , , |

A number of publications have appeared recently reporting on the efficacy and safety of cannabidiol (CBD) as an add-on therapy, as its clinical trials are concluding and its use is extending.  This paper describes an "expanded access" program - that is, when the FDA allows access to a drug before approval.  This is of [...]