The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model

By |2018-01-23T11:09:07+00:00November 23rd, 2017|Categories: DSF Research Review|Tags: , |

(Hawkins et al. 2017) Benzodiazepines like clobazam and diazepam target GABAA receptors located in the synaptic area of neurons. Other medication families, like neurosteroids, can target GABAA receptors beyond the synapses. In previous work, the authors found that a synthetic steroid, SGE-516, reduced seizures in one model of epilepsy. In this study, they tested the [...]