A transient developmental window of fast-spiking interneuron dysfunction in a mouse model of Dravet syndrome

By |2018-08-15T11:24:21-05:00August 15th, 2018|Categories: DSF Research Review|Tags: , , |

(Favero et al. 2018) Several years ago, researchers showed that Scn1a mutations in mice are primarily expressed in GABAergic interneurons, the inhibitory neurons that counteract excitatory neurons in the brain. A defect in these inhibitory neurons causes excess excitation, resulting in seizures and epilepsy in Dravet syndrome. However, that research was done primarily on brain [...]

Unexpected efficacy of a novel sodium channel modulator in Dravet syndrome

By |2017-05-10T19:56:54-05:00May 10th, 2017|Categories: DSF Research Review|Tags: , , , |

(Anderson LL et al. 2017). Sodium channel blockers usually make seizures worse in Dravet syndrome, which can be a confusing concept since we associate problems with the sodium ion channel due to SCN1A mutations leading to overexcitation and, hence, seizures. The key to understanding this apparent contradiction is that SCN1A is mainly expressed in inhibitory interneurons. [...]