Unexpected efficacy of a novel sodium channel modulator in Dravet syndrome

By |2017-05-10T19:56:54-05:00May 10th, 2017|Categories: DSF Research Review|Tags: , , , |

(Anderson LL et al. 2017). Sodium channel blockers usually make seizures worse in Dravet syndrome, which can be a confusing concept since we associate problems with the sodium ion channel due to SCN1A mutations leading to overexcitation and, hence, seizures. The key to understanding this apparent contradiction is that SCN1A is mainly expressed in inhibitory interneurons. [...]