Fine mapping of a Dravet syndrome modifier locus on mouse chromosome 5 and candidate gene analysis by RNA-seq

By |2016-11-17T19:45:23-05:00October 28th, 2016|Categories: DSF Research Review|Tags: , , |

(Hawkins, et. al. 2016). Because two people with the same SCN1A mutation can present with substantially different symptoms, often at opposite ends of the spectrum, scientists know there must be modifiers that affect how SCN1A mutations manifest in clinical severity. In fact, creating a Dravet syndrome mouse line is not as simple as inserting a [...]