A transient developmental window of fast-spiking interneuron dysfunction in a mouse model of Dravet syndrome

By |2018-08-15T11:24:21-05:00August 15th, 2018|Categories: DSF Research Review|Tags: , , |

(Favero et al. 2018) Several years ago, researchers showed that Scn1a mutations in mice are primarily expressed in GABAergic interneurons, the inhibitory neurons that counteract excitatory neurons in the brain. A defect in these inhibitory neurons causes excess excitation, resulting in seizures and epilepsy in Dravet syndrome. However, that research was done primarily on brain [...]