Pharmacological analysis of the anti-epileptic mechanisms of fenfluramine in SCN1A mutant zebrafish

By |2017-06-24T03:51:07-05:00May 8th, 2017|Categories: DSF Research Review|Tags: , , , |

(Sourbron J et al. 2017). Fenfluramine (FA) is known to affect serotonin (5-HT) levels in the brain, but there are several different 5-HT receptor subtypes that may be involved in FA's mechanism of action. This study explored the anti-epileptic mechanisms of FA in SCN1Lab-mutant zebrafish by selectively targeting each of the receptors believed to be involved [...]

Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome

By |2017-01-14T18:08:33-05:00January 14th, 2017|Categories: DSF Research Review|Tags: , , , , |

(Griffin, et. al 2017). Building on previous drug screening in a Dravet syndrome model of zebrafish that identified clemizole, a histamine (H1) receptor antagonist, as having anti-epileptic properties, this study sought to further examine the mechanisms of clemizole's action and expand the class of serotonin-acting compounds to include, among others, the FDA-approved drugs lorcaserin (Belviq) and [...]