(Hawkins et al. 2017) Benzodiazepines like clobazam and diazepam target GABAA receptors located in the synaptic area of neurons. Other medication families, like neurosteroids, can target GABAA receptors beyond the synapses. In previous work, the authors found that a synthetic steroid, SGE-516, reduced seizures in one model of epilepsy. In this study, they tested the neurosteroid on a mouse model of Dravet syndrome and found that it improved protection from hypothermia induced seizures, reduced spontaneous seizure frequency, and prolonged survival in the mice.

Hawkins NA, Lewis M, Hammond RS, Doherty JJ, Kearney JA. The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model. Sci Rep. 2017 Nov 10;7(1):15327. doi: 10.1038/s41598-017-15609-w. PubMed PMID: 29127345; PubMed Central PMCID: PMC5681541.