(Lagae et al. 2017) This survey of 584 mostly European caregivers of patients with Dravet syndrome took a different approach than the previous surveys, measuring the frequency of several different convulsive seizures and comparing seizure burden to comorbidities. Patients with the highest current seizure frequency (CSF) had more severely affected speech and motor profiles than those with the lowest CSF, but there was little difference between the two groups in terms of autism, ADHD, and other behavioral problems, suggesting seizure burden alone is not indicative of comorbidity severity.

Not surprisingly, Quality of life on a standardized scale for patients with DS was 0.46 points lower than for the general population and 0.38 points lower than for patients with epilepsy.

Lagae L, Brambilla I, Mingorance A, Gibson E, Battersby A. Quality of life and comorbidities associated with Dravet syndrome severity: a multinational cohort survey. Dev Med Child Neurol. 2018 Jan;60(1):63-72. doi: 10.1111/dmcn.13591. Epub 2017 Oct 6. PubMed PMID: 28984349.