(Wong, et. al. 2016). Huperzine-A, a molecule found in Chinese club moss, has been used for Alzheimer’s disease and age-related memory impairment. It inhibits the breakdown of the neurotransmitter acetylcholine, thus raising levels of acetylcholine. Although previous studies on zebrafish have not found Huperzine-A to have significant antiepileptic properties, this study found that Hup-A protected against electroshock-induced seizures and hyperthermia-induced seizures in both an SCN1A Dravet syndrome mouse model and an SCN1A GEFS+ mouse model. It also found that Hup-A, injected daily for 3 weeks, protected the GEFS+ mouse from further seizures. The study concluded that GABAA and muscarinic receptors play a role in Hup-A seizure protection.

Wong, J.C., Dutton, S.B., Collins, S.D., Schachter, S., Escayg, A. (2016). Huperzine A Provides Robust and Sustained Protection Against Induced Seizures in SCN1A Mutant Mice. Frontiers in Pharmacology, Oct 17;7:357. DOI: 10.3389/fphar.2016.00357.