Growth and endocrine function in children with Dravet syndrome

(Eschbach et al. 2017) The authors reviewed the charts of 68 patients with Dravet syndrome treated at Children’s Hospital Colorado. They found that the children’s height and weight fell further below average as the patient aged, and could not be attributed to gender, family history, or anti-seizure medications. Because height fell below normal before weight, the authors do not believe the reduced growth is the result of insufficient caloric intake as is seen in cases of failure to thrive. Although 12% of the patients had been on the ketogenic diet at some point, an extensive literature review did not identify weight loss as an adverse effect of the diet.

Endocrine testing was performed on 26 children, and 47% of those tested had abnormalities in insulin-like growth factor-1 (IGF-1). Testosterone levels were low in 20% of those tested.

Eschbach K, Scarbro S, Juarez-Colunga E, Allen V, Hsu S, Knupp K. Growth and endocrine function in children with Dravet syndrome. Seizure. 2017 Nov;52:117-122. doi: 10.1016/j.seizure.2017.09.021. Epub 2017 Sep 29. PubMed PMID: 29031192.
By |2018-01-22T16:16:37+00:00November 22nd, 2017|Categories: DSF Research Review|Tags: , , , |

About the Author:

Nicole is a former scientist and science educator who has an 11 year old son with Dravet syndrome and serves on the Board of Directors for the Dravet Syndrome Foundation. She reviews and summarizes research articles, making the content more accessible to those not involved in the scientific community.