Our Research Grant Program was established in 2010 to support investigator sponsored research in the field of Dravet syndrome, which historically has been critically underfunded. Our goal is to support and promote innovative approaches in Dravet syndrome research across disciplines to meet the critically important needs in patient care. Applicants should ensure their proposed project addresses the needs of the Dravet syndrome community and DSF’s mission to support research toward better treatments and a cure for Dravet syndrome. The peer review process is directed by the DSF Scientific Advisory Board (SAB) The SAB will receive, process, and evaluate submitted proposals. The program will support research from any field in Dravet syndrome, provided it is considered valued research at a recognized research institution. Applications for our 2021 Funding Cycle are due September 10, 2021.
DSF offers four types of funding: Research Grants, Clinical Research Grants, Clinician-Researcher Awards, and Postdoctoral Fellowships. Selection criteria are explained in each grant opportunity below. Applicants should be affiliated with a research or academic institution (excluding for-profit companies), may be US or foreign based, established in their field, and in good standing with their institution. Proposals are scored according to NIH guidelines based on the quality of preliminary data, research design, feasibility, investigator’s qualifications, and overall impact.
Research Grant Awards are intended for established, experienced, independent investigators affiliated with a research or academic institution whose proposed projects investigate hypotheses directly related to Dravet syndrome. Grants are awarded for $150,000 over 2 years, with indirect costs not to exceed 10% of the award. 2020 priority areas include:
Understanding the mechanisms of epileptogenesis in Dravet syndrome
Development of enhanced models to study Dravet syndrome
Understanding of the cellular, molecular, and genetic mechanisms that contribute to the pathogenesis of Dravet syndrome
Revealing causes and interventions for seizures and comorbidities in Dravet syndrome
Understanding causes and developing interventions for SUDEP
Development of novel treatments and interventions that will prevent the onset or halt the progression of Dravet syndrome; this includes research that may overcome the current size and delivery hurdles for gene-therapy approaches
Clinical Research Grant Awards are intended for proposed projects that have a clinical focus and investigate hypotheses directly related to Dravet syndrome. Grants are awarded for $150,000 over 2 years, with indirect costs not to exceed 10% of the award. 2020 priority areas include:
Research that helps identify patient trends, characteristics, epidemiology, or other clinical aspects of Dravet syndrome and/or its comorbidities
Research that helps to understand, predict, and prevent SUDEP
Research that will encourage the development of novel therapies to prevent onset or halt the progression of the Dravet syndrome
Clinician-Researcher Awards support hypothesis-driven clinical research projects that have significant potential to advance our understanding of Dravet syndrome; slow or halt the progression of the disease, characteristics, or comorbidities of the disease; and/or reduce mortality. The projects must be patient-oriented, with the investigator directly interacting with human subjects/patients. This includes studies such as therapeutic interventions or support/extension of existing clinical trials. Award funds of $75,000 for one year are to be used to support a minimum physician effort (salary and benefits) of 25%; funds may also be used to support a clinical trial specialist’s efforts or similar. No indirect costs are permitted.
Postdoctoral Fellowship Awards are designed to support early-career researchers under the mentorship of an independent investigator. These fellowships are awarded to qualified applicants whose proposed projects investigate hypotheses directly related to Dravet syndrome. Grants are awarded for $50,000, intended to support a full-time research effort with salary and benefits. No indirect costs are permitted.