Severe peri-ictal respiratory dysfunction is common in Dravet syndrome

By |2018-01-23T13:20:20-05:00January 23rd, 2018|Categories: DSF Research Review|Tags: , , |

(Kim et al. 2018) SUDEP is believed to be caused by cardiorespiratory arrest (or the stopping of the heart and breathing). However, it is not clear whether heart rate slows and stops, causing respirations to stop, or vice versa. Because SCN1A is expressed in heart tissue as well as brain tissue, scientists have hypothesized that SUDEP [...]

Sleep problems in Dravet syndrome: a modifiable comorbidity

By |2018-01-22T16:47:16-05:00January 22nd, 2018|Categories: DSF Research Review|Tags: |

(Licheni et al. 2017) 57 patients from Australia completed a sleep questionnaire, with 75% reporting problems. The most commonly reported problem was difficulty initiating and maintaining sleep, with sleep-wake transition disorders second most common. 53%  had nocturnal seizures. 16 patients were monitored by pulse oximetry overnight, and 14 of those had a higher than normal [...]

Quality of life and comorbidities associated with Dravet syndrome severity: a multinational cohort study

By |2018-01-22T15:59:17-05:00January 1st, 2018|Categories: DSF Research Review|Tags: , , |

(Lagae et al. 2017) This survey of 584 mostly European caregivers of patients with Dravet syndrome took a different approach than the previous surveys, measuring the frequency of several different convulsive seizures and comparing seizure burden to comorbidities. Patients with the highest current seizure frequency (CSF) had more severely affected speech and motor profiles than [...]