Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome.

By |2017-08-23T22:42:28+00:00August 23rd, 2017|Categories: DSF Research Review|Tags: , , |

(Grone B, et al. 2017). Anti-epileptic drug (AED) screening in zebrafish has proven efficient in models of Dravet syndrome due to the lower cost of maintaining fish compared with mouse colonies and rapid reproduction rates. The zebrafish used to study Dravet syndrome carry mutations in scn1lab (a zebrafish version of the human SCN1A gene) and are [...]

Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype.

By |2017-08-22T20:03:29+00:00August 22nd, 2017|Categories: DSF Research Review|Tags: |

(Sadleir L, et. al 2017). Dravet syndrome is often thought to be at the severe end of a spectrum of SCN1A disorders ranging from relatively mild conditions such as migraines to generalized epilepsy with febrile seizures plus (GEFS+) to DS. Even within the "severe" category of DS, patients can present with a wide degree of [...]

Life impact of caregiving for severe childhood epilepsy: Results of expert panels and caregiver focus groups

By |2017-08-22T19:32:00+00:00August 22nd, 2017|Categories: DSF Research Review|Tags: |

(Jensen MP, et al. 2017). Through focus groups and interviews with a group of clinician experts and caregivers, this study sought to identify the ways in which severe epilepsy impacts caregivers. In the first part of the study, an expert panel of eight pediatric neurologists identified nine impact areas as potentially important to caregivers: 1. [...]

Dravet syndrome: Characteristics, comorbidities, and caregiver concerns

By |2017-08-22T18:16:15+00:00August 22nd, 2017|Categories: DSF Research Review|

This article summarizes the various challenges patients with Dravet syndrome and their caregivers face. It is an analysis of an in-depth online survey posted in the DSF support group in 2016 covering comorbid health conditions, characteristics of the syndrome, and the top caregiver concerns. Because it is written in layman's terms, it does not need [...]