Welcome to DSF’s Research Review! We will use this space to keep you up to date on the most exciting studies that are published each month on Dravet and SCN1A. Each review includes a link to the original abstract or article (where possible), as well as a lay-person’s summary. We divide the research into two sectors: Clinical research and Basic Science/Pre-Clinical Research. Have questions? Email Nicole: Nicole.v@dravetfoundation.org

Summer 2016 Research Review

I apologize for the long gap between this research review and the last one. With so many articles to reference, this review is divided into three parts: SCN1A-related studies, Clinical studies, and Basic Science studies. References and links (where available) are located at the end of the review.   SCN1A:   Two new cases of […]

May/June Research

May and the first part of June saw a surge in Dravet syndrome publications. Nearly half of those publications were from one journal, The Canadian Journal of Neurological Sciences. This journal ran a 23-page series of 5 articles focused on Dravet featuring an introduction and conclusion by Dr. Charlotte Dravet, sandwiching three articles on diagnosis and […]

April Research

Welcome back! The peer-reviewed literature relevant to Dravet that was published in April focused on investigations at the gene level, with one exception for a zebrafish metabolism study. We are still working on the best format for this blog, so please let us know if you have any feedback!   1. Overview of Models of […]

March Research

March was a busy month for Dravet research! Here we highlight 4 studies on SCN1A variants (including the latest hot topic, mosaicism, and how mutations relate to cognitive impairment); a review of medications used for Dravet (co-authored by one of our very own Medical Advisory Board members); a new transcutaneous VNS device; a small study […]

February Research

Those who have difficulty accepting the fact that no one is entirely sure how many anti-epileptic drugs work will find solace in research published in the last two months, which gives us several insights into why certain medications such as stiripentol and CBD might help control seizures. Two studies on STP and one on CBD […]

Research Published December 2015 and January 2016

Clinical Research: Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. (Lancet Neurology, Dec. 2015) (http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00379-8/fulltext)   Data from the first large safety and tolerability study on GW Pharmaceuticals’ Epidiolex, a highly purified extraction of plant-based cannabidiol (CBD), was published. The study, led by Dr. Orrin Devinsky and clinicians across the US, included 214 […]